Weekly paclitaxel protocol metastatic breast cancer

Find Metastatic Cancers. Search a wide range of information from across the web with searchinfotoday.com Over 80% New & Buy It Now; This is the New eBay. Find Great Deals now! Check Out Top Brands on eBay. Fill Your Cart With Color today A weekly schedule, at a median dose-intensity of 91 mg/m2, is effective and has less side effects than a 3-week schedule. In this phase II study, we evaluated the toxicity and the activity of weekly 1 hr paclitaxel infusions in metastatic breast cancer patients. Study design: Between February 1999 and February 2001, 26 patients with metastatic. Weekly paclitaxel versus 3 weekly paclitaxel, with trastuzumab in metastatic Breast Cancer. r The Cancer and Leukaemia Group B (CALGB) conducted a randomised phase III trial (CALGB 9840) to determine whether weekly paclitaxel (100 mg/m 2 initially, modified to 80 mg/m 2 after initial weeks of therapy) is more effective and less toxic than 3. Palliative therapy for advanced breast cancer where initial chemotherapy with an anthracycline has failed or is inappropriate. (NICE CG81) ICD-10 codes Codes pre-fixed with C50. Regimen details 21 day cycle Day Drug Dose Route 1, 8, 15 Paclitaxel 80*mg/m² IV infusion 28 day cycle Day Drug Dose Rout

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  1. istered as a biweekly 1-h infusion (120 mg/m2). METHODS: Twenty patients with metastatic breast cancer were enrolled in this study. Paclitaxel was ad
  2. breast cancer using weekly paclitaxel (3 weeks out of 4 weeks schedule) Other names: BRAVTW . BR Breast. AV Advanced. TW Paclitaxel (TAXOL®) weekly. Uses: • BRAVTW is a drug treatment given as therapy for metastatic breast cancer in the hope of destroying breast cancer cells that have spread to other parts of your body. This treatmen
  3. Approved for metastatic breast cancer where initial anthracycline-containing chemotherapy has failed or is inappropriate. Paclitaxel can also be used in combination with 3-weekly Herceptin in patients with HER2 positive tumours (see Herceptin protocol). PREMEDICATIO
  4. 1. Seidman AD, Hudis CA, Albanel J, Tong W, Tepler I, Currie V, et al. Dose-dense therapy with weekly 1-hour paclitaxel infusions in the treatment of metastatic breast cancer. J Clin Oncol. 1998:16:3353- 61. 2. Perez EA, Vogel CL, Irwin DH, et al. Multicenter phase II trial of weekly paclitaxel in women with metastatic breast cancer
  5. bound nab-paclitaxel or ixabepilone with or without bevacizumab as first line therapy for locally recurrent or metastatic breast cancer. J Clin Oncol 2012;30(18)suppl:CRA1002 3. Perez EA, et al. Multicenter phase II trial of weekly paclitaxel in women with metastatic breast cancer. J Clin Oncol 2001;19(22):4216-23. 4
  6. Weekly Paclitaxel Is Effective in Advanced Breast Cancer Study. SAN ANTONIO-A weekly outpatient paclitaxel (Taxol) regimen led to rapid responses in more than 40% of a group of heavily pretreated women with metastatic breast cancer, said Dr. Hans-Joachim Luck, of the Medical University of Hannover, Germany
  7. Seidman AD, Fornier MN, Esteva FJ, et al. Weekly trastuzumab and paclitaxel therapy for metastatic breast cancer with analysis of efficacy by HER2 immunophenotype and gene amplification. J Clin.

Weekly Compared With Every-3-Weeks Paclitaxel for Metastatic Breast Cancer, With Trastuzumab for all HER-2 Overexpressors and Random Assignment to Trastuzumab or Not in HER-2 Nonoverexpressors: Final Results of Cancer and Leukemia Group B Protocol 9840 2. Joseph A. Sparano, M.D., Molin Wang, Ph.D., Silvana Martino, D.O., Vicky Jones, M.D., Edit BREAST CANCER TREATMENT REGIMENS (Part 3 of 6) REGIMEN DOSING Recurrent or Metastatic Breast Cancer—Combination Therapy (continued) AT (doxorubicin + paclitaxel)1,20 Day 1: Doxorubicin 60mg/m 2 IV + paclitaxel 125-200mg/m 2 IV. Repeat cycle every 3 weeks Breast Pathway Group - Paclitaxel weekly in Early Breast Cancer Indication: Neoadjuvant or adjuvant alternative therapy to docetaxel, for high risk patients unable to tolerate docetaxel or where there is a contraindication for high dose steroids Regimen details: Paclitaxel 80 - 90mg/m2 IV Day The findings are also consistent with the results of trials of metastatic breast and prostate cancer that indicate that docetaxel may be more effective if given every 3 weeks rather than weekly. Dose-dense paclitaxel (paclitaxel given on a frequent or weekly schedule) has been shown to be a safe and effective treatment of metastatic breast cancer, inducing tumor responses in more than 50% of patients with metastatic breast cancer. 10,11 Recent retrospective data evaluating patients with metastatic breast cancer has demonstrated that.

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Use: For the treatment of breast cancer after failure of combination chemotherapy for metastatic disease or relapse within 6 months of adjuvant chemotherapy; prior therapy should have included an anthracycline unless clinically contraindicated. Usual Adult Dose for Breast Cancer - Adjuvant. For adjuvant treatment of node-positive breast cancer Locally advanced breast cancer Metastatic breast cancer Dosage Drug Dose Route Frequency Paclitaxel 80mg/m2 IV Infusion Every 7 days Treatment is repeated weekly for 12 weeks followed by review. Treatment can continue beyond 12 weeks if clinical benefit and acceptable toxicity Memorial Sloan-Kettering Cancer Center IRB Protocol IRB#: 08-122 A() Amended: 06/15/15 - 6 - 1.0 PROTOCOL SUMMARY AND/OR SCHEMA This trial is phase I-II study of dasatinib in combination with weekly paclitaxel for patients with advanced and metastatic breast carcinoma Between February 1999 and February 2001, 26 patients with metastatic breast cancer were treated with weekly paclitaxel (60-90 mg/m 2 /1 hour iv infusion/weekly). The treatment was planned to continue until disease progression or prohibitive toxicity; in patients with responsive or stable disease, paclitaxel was stopped after 6 months of therapy I ntroduction. An estimated 215,990 women will be diagnosed with breast cancer in the U.S. in 2005, and 40,110 deaths are expected to result from the disease [].For most women diagnosed with metastatic breast cancer (MBC), median survival durations of 18-36 months after diagnosis are common, with survival longer than 5-10 years reported in some cases []

Feasibility of AC/EC Followed by Weekly Paclitaxel in Node

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Paclitaxel has demonstrated efficacy at 175 mg/m 2 in metastatic breast cancer, recurrent breast cancer and node-positive breast cancer. Paclitaxel has demonstrated superior efficacy using a weekly administration schedule of 80 mg/m 2 in these settings, but is not approved by the US Food and Drug Administration for this dose Treatment of locally recurrent metastatic triple negative breast cancer. PACLitaxel Monotherapy 80mg/m2 Day 1, 8, 15 and 22 - 28 Day. Regimen. 00226a * Treatment of metastatic breast carcinoma (mBC) in patients who have either failed or are not candidates for standard, anthracycline-containing therapy. Tamoxifen. Regimen. 00253 Sixty-one metastatic breast cancer patients showing 2 + or 3 + HER2 + expression by immunohistochemistry received induction therapy with trastuzumab followed by weekly paclitaxel (70 mg/m 2), carboplatin (AUC 2), and trastuzumab (2 mg/kg) for 6 of every 8 weeks. The overall response rate for all patients was 66%, with a median overall survival. Seidman AD, Berry D, Cirrincione C, et al. Randomized phase III trial of weekly compared with every-3-weeks paclitaxel for metastatic breast cancer, with trastuzumab for all HER-2 overexpressors and random assignment to trastuzumab or not in HER-2 nonoverexpressors: final results of Cancer and Leukemia Group B protocol 9840

Metastatic breast cancer (also called stage IV or advanced breast cancer) is not a specific type of breast cancer. It's the most advanced stage of breast cancer. Metastatic breast cancer is breast cancer that has spread beyond the breast and nearby lymph nodes to other parts of the body (most often the bones, lungs, liver or brain) Carboplatin Abraxane.pdf Metastatic Breast Cancer algo v2.0.pdf (Neo-)Adjuvant Breast algo table 2.0.pdf CA Breast NSSG Key Docs Cancer CSG report_Breast 18-19.pptx NSSG attendance for Breast 2018-19.pdf Terms of Reference 2017 - 2020.pdf Breast Clinical Network Guidelines.pdf Breast NSSG - Achievements 2016-17.pd

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Weekly paclitaxel in metastatic breast cancer patients: a

The 3-weekly combination of trastuzumab and paclitaxel has been approved for the treatment of advanced breast cancer based on a large pivotal study. However, mono and combination chemotherapy trials suggest that weekly paclitaxel has a better therapeutic index, especially in the palliative setting. The present trial examined the efficacy and safety of weekly paclitaxel over a limited duration. Nishimura, R. et al. Weekly Paclitaxel in the treatment of advanced or metastatic breast cancer previously treated or not treated with Docetaxel: a phase II study. Chemotherapy 51 , 126-131 (2005)

42-Breast metastatic PACLitaxel weekly evi

examined the efficacy and safety of weekly paclitaxel over a limited duration combined with continued trastuzumab in HER2+ patients. Methods: Patients with histologically confirmed metastatic breast cancer overexpressing HER2 were eligible if pretreated with anthracycline in either the adjuvant or palliative setting Weekly paclitaxel is regarded as a standard of care in metastatic breast cancer due to improvements in efficacy and tolerability seen with this schedule . The Cancer and Leukemia Group B (CALGB 9840) demonstrated that weekly paclitaxel was superior to every 3-week paclitaxel as treatment of metastatic breast cancer with improvements seen in RR. A. D. Seidman, D. Berry, C. Cirrincione et al., Randomized phase III trial of weekly compared with every-3-weeks paclitaxel for metastatic breast cancer, with trastuzumab for all HER-2 overexpressors and random assignment to trastuzumab or not in HER-2 nonoverexpressors: final results of cancer and leukemia group B protocol 9840, Journal. This is a two arm Phase III trial in first and second-line HER2 negative patients with locally recurrent or metastatic breast cancer. The primary endpoint is overall survival (OS), and the objective is to test for the superiority of eribulin mesylate over standard weekly paclitaxel

An Open‐Label Safety Study of Lapatinib Plus Trastuzumab

The safety of dose-dense doxorubicin and cyclophosphamide followed by paclitaxel with trastuzumab in HER-2/neu overexpressed/amplified breast cancer. J Clin Oncol . 2008;26:1216-1222. 62 The efficacy and safety of gemcitabine plus paclitaxel combination first-line therapy for Japanese patients with metastatic breast cancer including triple-negative phenotype By Kenjiro Aogi The pipeline of new anticancer agents for breast cancer treatment in 200

Taxanes are one of the most common chemotherapy agents for metastatic breast cancer. Weekly addition of paclitaxel to the combination therapy regimen including fluorouracil (an anti-metabolite), epirubicin (an alkylating agent), and cyclophosphamide (an immunosuppressant) show a 47% reduced recurrence rate and an 18% enhancement of 7-year. The initial protocol for the international, randomized, phase 3 KX-ORAX-001 study (NCT02594371)—designed to evaluate oral paclitaxel at 205 mg/m 2 plus 15 mg of encequidar 3-times-weekly or IV paclitaxel at 175 mg/m 2 every 3 weeks in 402 patients with metastatic breast cancer 2 —did not allow the use of antiemetics in either group. However. Kinetic-Pharmacodynamic Model of Chemotherapy-Induced Peripheral Neuropathy in Patients with Metastatic Breast Cancer Treated with Paclitaxel, Nab-Paclitaxel, or Ixabepilone: CALGB 40502 (Alliance). AAPS J. 2017 Sep;19(5):1411-1423. doi: 10.1208/s12248-017-0101-9. Epub 2017 Jun 15 Eligible patients had HER2-overexpressing, metastatic breast cancer and had received no prior chemotherapy for advanced disease. Patients were randomized 1:1 to receive either trastuzumab with weekly vinorelbine therapy or weekly taxane therapy (paclitaxel or docetaxel at the investigator's choice) The trial recruited patients with inoperable, locally-advanced triple-negative breast cancer who had not previously received advanced therapy, said Peter Schmid, MD, PhD, of Barts Cancer Institute in London, who was one of the study authors. Patients were randomized to atezolizumab plus nab-paclitaxel (n=255) or placebo plus nab-paclitaxel (n=279)

Paclitaxel, Carboplatin Regimen Shows Promise in Triple-Negative Breast Cancer. September 17, 2020. Ryan McDonald. This randomized clinical trial found that compared with the conventional anthracycline and docetaxel regimen, the paclitaxel-plus-carboplatin regimen may be an alternative adjuvant chemotherapy strategy for patients with. Randomized phase III trial of weekly compared with every-3-weeks paclitaxel for metastatic breast cancer, with trastuzumab for all HER-2 overexpressors and random assignment to trastuzumab or not in HER-2 nonoverexpressors: final results of Cancer and Leukemia Group B protocol 984 A phase II study of docetaxel in patients with paclitaxel-resistant metastatic breast cancer. J Clin Oncol 1998; 16:3362-8. 12. Gradishar W, Krasnojon D, Cheporov S, et al. A randomized phase 2 trial of qw or q3w ABI-007 (ABX) vs. q3w solvent-based docetaxel (TXT) as first-line therapy in metastatic breast cancer (MBC) Table 1. nab-Paclitaxel monotherapy in metastatic breast cancer ; Trial Phase Patient population nab-Paclitaxel regimen Patients receiving protocol-specified dose (%) Efficacy outcomes Select. Abstract. Background.We performed a randomized phase II study comparing efficacy and toxicity of weekly paclitaxel 80 mg/m 2 (Weetax) with three weekly docetaxel 75 mg/m 2 (Threetax), both in combination with oral capecitabine 1000 mg/m 2 twice daily for 2 weeks followed by a 1-week break. Patients.Thirty-seven women with confirmed metastatic breast cancer were randomized

  1. To establish the safety and tolerability of ACY-1215 (ricolinostat) in combination with weekly nab-paclitaxel in patients with metastatic breast cancer. II. To assess progression free survival (PFS), the overall response rate (ORR), and clinical benefit rate (CBR) in the study population
  2. e whether neratinib-paclitaxel was superior to trastuzumab-paclitaxel as first-line treatment for women with metastatic ERBB2-positive breast cancer (Trial Protocol is available in Supplement 1)
  3. Randomized phase III trial of weekly compared with every-3-weeks paclitaxel for metastatic breast cancer, with trastuzumab for all HER-2 overexpressors and random assignment to trastuzumab or not in HER-2 nonoverexpressors: final results of Cancer and Leukemia Group B protocol 9840. J Clin Oncol. 2008; 26(10):1642-9 (ISSN: 1527-7755
  4. Yu K-D, Ye F-G, He M, et al. Effect of adjuvant paclitaxel and carboplatin on survival in women with triple-negative breast cancer: a phase 3 randomized clinical trial. JAMA Oncol
  5. istered only on Day 1 at a lower dose (175 mg/m 2 i.v. every 3 weeks) compared with cisplatin/paclitaxel and cisplatin/gemcitabine. Dose modifications and intensity of dose delivery were not reported
  6. ation between metastatic tumors and primary 8). The frequency of breast metastasis of ovarian carcinoma breast carcinomas are usually done by clinical and patho- varies from 0.5 to 1.2% in the clinical setting (9-11)

Two studies presented Dec. 9, 2015 at the 2015 San Antonio Breast Cancer Symposium suggest that adding carboplatin to the standard chemotherapy regimen before surgery may improve outcomes for women diagnosed with triple-negative disease. Treatment given before surgery to weaken or shrink the cancer is called neoadjuvant treatment Sequential FEC + paclitaxel effective in metastatic breast cancer. Abstract. Inpharma 1304 - 8 Sep 2001 Fluorouracil, epirubicin and cyclophosphamide (FEC), followed by paclitaxel, may have better tolerability than combined anthracycline-paclitaxel schedules, with at least similar efficacy, in patients with progressive metastatic breast cancer, comment investigators from Italy In metastatic breast cancer, nab-paclitaxel has been shown to significantly increase progression-free survival compared with solvent-based paclitaxel. The GeparSepto (GBG 69) trial assessed whether weekly nab-paclitaxel could increase the proportion of patients achieving pathological complete response compared with weekly solvent-based. Nab-paclitaxel (Abraxane) proved markedly more effective than conventional paclitaxel as part of a neoadjuvant regimen for patients with high-risk early breast cancer in a large German study. The chemotherapy regimen known as FOLFIRINOX is the only treatment that has been shown in a clinical trial to improve the survival of patients with metastatic pancreatic cancer. Nab-paclitaxel is a form of the chemotherapy drug paclitaxel that is bound to the human protein albumin and contained in nanoparticles

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Paclitaxel is an integral part of the chemotherapy options for women with breast cancer. It is used in both adjuvant treatment and metastatic disease [6-9]. We conducted a retrospective analysis of two large randomized trials of paclitaxel in the metastatic setting to determine its efficacy and toxicity among different age groups Oligometastatic Breast Cancer. NRG ‐ BR003. III A Randomized Phase III Trial of Adjuvant Therapy Comparing Doxorubicin Plus Cyclophosphamide Followed by Weekly Paclitaxel with or Without Carboplatin for Node‐Positive or High‐Risk Node‐Negative Triple‐Negative Invasive Breast Cancer. NRG ‐ BR004. II 5. Documentation of HER2 negative breast cancer at the time of protocol registration. [Note: HER2 negativity is defined as 0 or 1+ by immunohistochemistry OR nonamplified or equivocal by FISH. Status may be defined on the basis of historic results on the breast primary or a metastatic site, whichever is most recent Find Related Search Prognosis Metastatic Breast Cancer Randomized phase III trial of weekly compared with every-3-weeks paclitaxel for metastatic breast cancer, with trastuzumab for all HER-2 overexpressors and random assignment to trastuzumab or not in HER-2 nonoverexpressors: final results of Cancer and Leukemia Group B protocol 9840

Biweekly paclitaxel in patients with metastatic breast cancer

  1. ister Herceptin, alone or in combination with paclitaxel, at an initial dose of 4 mg/kg as a 90-
  2. istration for metastatic breast cancer (MBC). Cancer and Leukemia Group B (CALGB) protocol 9840 was initiated to address this question
  3. Optimal management of breast cancer in the elderly patient: current perspectives By Bertrand Ripamonti Safety and Efficacy of the Multidrug Resistance Inhibitor Incel (Biricodar; VX-710) in Combination with Paclitaxel for Advanced Breast Cancer Refractory to Paclitaxel
  4. istered sequentially on days 1, 8 and 15 every 28 days

Trastuzumab and Weekly Paclitaxel in HER2-Overexpressing Metastatic Breast Cancer be incorporated into on- and off-protocol patient care. This activity will assist medical oncologists, radiation oncologists, breast/general Paclitaxel in HEr2-overexpressing Metastatic Breast Cancer. With this in mind, should she be seeking to push a more aggressive treatment approach in the following ways: adding carboplatin to the taxol cycles. changing taxol treatments to weekly (12 weeks), her prescribed protocol was dose dense every two weeks for 8 week. Curious to hear your guys chemotherapy protocols for TNBC. Thanks for the input for-the-management-of-breast-cancer-v1.doc 8 . Organisation of breast cancer surgical services . The multidisciplinary team (MDT) Breast cancer care should be provided by breast specialists in each disciplineand multidisciplinary teams form the basis of best practice. All new breast cancer patients should be reviewed by a multi-disciplinary.

Weekly Paclitaxel Is Effective in Advanced Breast Cancer Stud

Citation Format: Rabizadeh S, Simon B, Klingemann H, Sims D, Weiss R, Soon-Shiong P. Novel protocol combining metronomic nant-paclitaxel with HER2-targeted natural killer cells (innate immunotherapy) for HER2-positive metastatic breast cancer. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium. Metastatic triple-negative breast cancer (mTNBC) comprises 15% to 20% of all breast cancer diagnoses [].Patients with mTNBC tend to be diagnosed at a younger age and have a worse prognosis than those with other subtypes of breast cancer [2,3,4].A chart review study suggested that most, but not all, patients with mTNBC in US community practices receive a systemic treatment (83%); the observed.

Breast Cancer (Recurrent or Metastatic) Treatment Regimens

Therefore, based on recent evidence, FEC 100 followed by weekly paclitaxel was selected as the standard NAC regimen most likely to have a maximal effect on locally advanced operable breast cancer. In this study, we present the treatment results and discuss the clinical significance of this NAC protocol for operable breast cancer patients Neoadjuvant dual human epidermal growth factor receptor (HER2) blockade with trastuzumab and pertuzumab plus paclitaxel leads to an overall pathologic complete response (pCR) rate of 46%. Dual HER2 blockade with ado-trastuzumab emtansine (T-DM1) and lapatinib plus nab-paclitaxel has shown efficacy in patients with metastatic HER2-positive breast cancer Data from reports in metastatic breast cancer indicated that nab-paclitaxel, the nano-particle, albumin-bound paclitaxel (Abraxane, Celgene Corp), has improved antitumor activity than solvent-based paclitaxel, 10 although this superiority was not confirmed in a more recent trial. 11 The formulation allows for safe infusion without the steroid. The paclitaxel dose and schedule chosen for this study (80 mg/m 2 weekly) reflects a general trend towards more frequent use of dose-dense paclitaxel and is consistent with standard practice in other solid tumours, such as ovarian cancer and non-small-cell lung cancer, in which carboplatin-paclitaxel is the standard of care. However, in such. Studies of nab-paclitaxel in early-stage breast cancer Unselected (all subtypes) Among 7 phase II and III studies of neoadjuvant nab-paclitaxel (majority administered weekly) that did not select for specific disease subtype, the pathological complete response (pCR) rate ranged from 22 to 40%; 4 phase II studies included <50 patients (Table 1).. A trend toward benefit for stage II disease was.

Weekly Paclitaxel in the Adjuvant Treatment of Breast Cance

  1. -bound paclitaxel (nab-paclitaxel) is approved to be given every 3 weeks, weekly use of this drug is beco
  2. Checkpoint Inhibitor in Advanced Breast Cancer Addition of the anti-PD-L1 antibody atezolizumab to nab-paclitaxel as first-line therapy for patients with advanced or metastatic triple-negative brea..
  3. imizing toxicity. New strategies to achieve these goals worldwide are.
  4. 3.6 IMpassion130 is a double-blind randomised clinical trial comparing atezolizumab plus nab‑paclitaxel against placebo plus nab‑paclitaxel in people with triple-negative advanced breast cancer who have not had previous treatment for metastatic disease. Nine treatment centres in the UK (44 patients) were included in the trial
  5. December 11, 2020 - Gastrointestinal adverse events that occurred in patients with metastatic breast cancer who were treated with oral paclitaxel and encequidar can be managed by the use of 5- HT3.
  6. Although drug combinations are often used to treat early breast cancer, advanced breast cancer more often is treated with single chemo drugs. Still, some combinations, such as paclitaxel plus gemcitabine, are commonly used to treat advanced breast cancer. For cancers that are HER2-positive, one or more drugs that target HER2 may be used with chemo
  7. A Phase 1b Trial of Cirmtuzumab and Paclitaxel in Locally Advanced/Unresectable or Metastatic Her2 Negative Breast Cancer Rebecca A. Shatsky MD1, Teresa Helsten MD1, Richard B Schwab MD1, Emily I. Pittman PhD1, Ruifeng Chen1, Elizabeth Weihe MD1, George Widhopf PhD1, Emanuela M. Ghia PhD1, Laura Z. Rassenti PhD1, Alfredo MolinoloMD PhD1, James Breitmeyer MD PhD2, Catriona H. M. JamisonMD PhD1.

Weekly Paclitaxel Improves Pathologic Complete Remission

Paclitaxel & Trastuzumab Breast Cancer Protoco

We evaluated the efficacy and safety of weekly paclitaxel plus trastuzumab as firs-tline chemotherapy in women with HER2-overexpressing metastatic breast cancer (MBC), and we investigated the prognostic factors including magnitude of HER2/neu amplification in this population. We analyzed 54 patients with HER2-overexpressing MBC that were treated with weekly paclitaxel plus trastuzumab as first. Background Paclitaxel plays a central role in chemotherapy for breast cancer. Peripheral neuropathy, a well-known toxicity with paclitaxel, may be of interest in predicting the efficacy of paclitaxel therapy for patients with metastatic breast cancer. We performed a retrospective analysis assessing whether the early occurrence of peripheral neuropathy (EPN) was a predictive marker for better.

METTEN study designMETTEN trial profileβ2-AR signaling controls trastuzumab resistance-dependent