Men's grooming made easy - top quality grooming essentials for every price range. Explore Hanz De Fuko, Regenerate, Jack Black, Bull Dog and other Mankind favourites Free UK Delivery Over £25. Download Our App For Exclusive Offers. With Luxury Brands And Unbeatable Offers, LOOKFANTASTIC Is The Home Of Online Beauty SSB antibodies are found primarily in patients with Sjogren syndrome or SLE, where they occur with frequencies of approximately 60% and 15%, respectively. (1,2) SSB antibodies occur only infrequently in the absence of SSA antibodies. See Connective Tissue Disease Cascade (CTDC) in Special Instructions
I was just told by a new rhematologist that normally someone with Sjogren's will have a relatively high titer, like 80 or 90 and that even 5 is pretty low. She questions my results and is repeating the bloodwork. My previous doc told me if you test positive, even once, it means you definitely have SjS The antibodies Anti-SSA (Ro) and Anti-SSB (La) are present in 70-80% of individuals with Sjogren's syndrome, and about 30% of people living with lupus show markers for these antibodies as well. <0.2 can mean you don't have sjorgren's syndrome and you are likely to have lupu Anti-Nuclear Antibody (ANA): Anti-Nuclear Antibodies react against normal components of cell nuclei and are present in about 70 percent of Sjögren's patients. Rheumatoid Factor (RF): This test usually is recommended when rheumatoid arthritis is suspected, but 60 to 70 percent of Sjogren's patients test positive However, in the case of autoimmune diseases such as Sjogren's and lupus, the antibodies tag your own cells. The antibodies Anti-SSA (Ro) and Anti-SSB (La) are present in 70-80% of individuals with Sjogren's syndrome, and about 30% of people living with lupus show markers for these antibodies as well
Sjögren disease is an autoimmune condition that makes it hard for your glands to make enough moisture. The condition causes discomfort by drying out mucous membranes, including the ones in the mouth, eyes, nose, lungs, and vagina. Sjögren may also affect the joints, kidneys, and the nervous, vascular, respiratory, and digestive systems After the Test. Interpreting Results. Sjögren's antibodies include anti-SS-A (also called anti-Ro) and anti-SS-B (also called anti-La). These antibody levels can be measured in the blood. Anti-SS-A and anti-SS-B are considered autoantibodies. They contribute to disease by attacking the body's own tissue. Elevated levels of these. Anti-La Blood Test: This blood test has a positive result about 60% of the time with Sjogren's syndrome. SCL-70 Blood Test: There is a positive result seen in about 60% of those who have scleroderma. It is highly specific for this disease only, so it functions in much of the same way as the SSA blood test
Clinical, serologic, and genetic findings in Sjögren's syndrome patients were correlated with quantitative determinations for antibody against Ro (SS-A), La (SS-B), and nRNP (Sm) using newly developed, sensitive solid-phase assays. In 86 Sjögren's syndrome patient sera, more than 96% had anti-Ro (SS SSa (Ro) antibodies are primarily seen in Sjogren's syndrome where they're usually accompanied by SSb (La) antibodies. SSa antibodies are also seen in 30-40 percent of systemic lupus erythematosus (SLE) cases, and 5-10 percent of individuals with progressive systemic sclerosis (PSS) and 5 percent of individuals with polymyositis
All median values of sex steroid hormones were within the range of normal for pSS cases. Positive correlations were noted between testosterone and ESR (r = 0.36, p = 0.03), testosterone and serum protein (r = 0.37, p = 0.05), and testosterone and focus score (r = 0.44, p = 0.007) High ANA but Anti-SSA and Anti-SSB have been normal twice. I recently came across this article which said: Although practitioners often rely on SS-A and SS-B antibodies to screen for Sjögren syndrome, 26% to 67% of Sjögren syndrome patients do not have the SS-A antibodies, and 48% to 77% do not have the SS-B antibodies.6 SS-A/SS-B.
An autoimmune workup showed polyclonal IgG elevation, with anti-SSA/Ro values of 4.1 (positive) and anti-SSB/La of >5.0 (strongly positive). However, her complement 3 was 81 mg/dL (normal range 85-185) and complement 4 was 30 mg/dL (normal range 10-50), with a negative anti-dsDNA ANA positivity was present in 70.6% patients, anti-SSA positivity in 47.1%, and double positivity of anti-SSA and anti-SSB in 17.6%. There were 12 patients (70.6%) with two autoimmune diseases (pSS and MG), and five patients with more than two autoimmune diseases On 9-24-10 I had blood work performed due to pain in several joints. ANA returned positive. Lupus comp panel showed SM Antibody reference range 0-19, my result was 23, SMITH Antibodies reference range 0.0-0.9, my result was less than 0.2, RNP Antibodies reference range 0.0-0.9, my result was less than 0.2, Sjogrens SS-A reference range 0.0-0.9, my result was greater than 8.0, Sjogrens SS-B. Peripheral neuropathy is one of many extra-glandular manifestations in primary Sjogren's Syndrome (pSS), an autoimmune disease that affects approximately 0.6 percent to one percent of adults in the United States. 1 A review of the literature from 1990 to 2010 suggests that the prevalence of peripheral neuropathy seen in pSS ranges from 1.8 percent to 64 percent. 2 More recently, a 2013 study. I have the same problem, the last 8 months, my mum was diagnosed with Sjogren's a few months before she died with secondary problems but she didnt know if she was diagnosed with primary Sjogren's she could of prevented secondary problems. Now I am finding it hard to get to see a Sjogren's specialist in Enland. July 30, 2011 at 8:44 A
Anti SSB antibodies are primarily anti-nuclear antibodies which are associated with various autoimmune diseases. It mainly includes systemic lupus erythematosus (SLE), SS/SLE overlap syndrome, subacute cutaneous, primary biliary cirrhosis etc. Anti SSB antibody blood test is done to determine whether SSB antibody is present in the blood or not Hi Deb - Thanks for writing and sharing your concerns. Here's what the Scleroderma Foundation says in an article titled Sjogren's 101 Laboratory Tests Only half of Sjögren patients have anti-SSA and/or anti-SSB (Sjögren's Syndrome A and B) antibodies in their blood Sjögren syndrome is an autoimmune disease characterized by lymphocytic infiltration of exocrine glands that results in dry eyes and dry mouth; other common symptoms include fatigue and joint pain. The disease may affect as many as four million people in the United States and is one of the more prevalent connective tissue or systemic autoimmune rheumatic diseases (SARDs) The sensitivity of the anti-SSA/Ro assay for SS is about 8-70%, and the specificity is 87%.They seem to be associated with primary SS forms with vasculitis and leucopenia By David Ivanov, Biochemistry and Molecular Biology, 2015 Sjogren's syndrome, like other autoimmune diseases, can be difficult to diagnose definitively, and often relies on a handful of signs and symptoms that can vary substantially from case to case. The only signs considered markers for Sjogren's are anti-SSA and anti-SSB antibodies, and while anti-SSB is mor
In an autoimmune disease, the immune system mistakenly attacks healthy tissue, causing inflammation in the body and leading to the destruction of tissue. In Sjögren's syndrome, the infection-fighting cells of the immune system (called lymphocytes) attack the normal cells of exocrine glands - the glands that produce moisture in the eyes. Further autoimmune tests showed positive anti-nuclear antibodies (ANA) 1:1000 and anti-SSA antibody; however, normal serum complements levels. Since she was diagnosed as autoimmune adrenal insufficiency (AI), prednisone replacement therapy (5 mg 8 am and 5 mg 4 pm each day) has been maintained for more than 20 years Many Sjogren's syndrome symptoms respond well to self-care measures. To relieve dry eyes: Use artificial tears, an eye lubricant or both. Artificial tears — in eyedrop form — and eye lubricants — in eyedrop, gel or ointment form — help relieve the discomfort of dry eyes. You don't have to apply eye lubricants as often as artificial tears
Bragoni et al Sjogren's Syndrome and Ischemic Stroke 2277 Magnetic resonance images show two areas of hyperintensitrywelghte on T d image (right panel) and corresponding hypointenstty on T,-weighted image (left paneO In the territory of the left middle cerebral artery, involving the cortex of the insuia and the giobus paiiidum (Figure 2). Her autoimmune serologies were positive for ANA (> 1:1280 antibody titer) and anti-SSA, and negative for anti-SSB. She also had low complement levels. Other autoimmune serologic markers were negative, including anti-ds DNA, anti-smooth muscle antibody (SMA), anti-mitochondrial antibody (AMA), RNP, c-ANCA, and p-ANCA
SS-A/Ro is 1 of 4 autoantigens commonly referred to as extractable nuclear antigens (ENA). The other ENA are SS-B/La, RNP, and Sm. Each ENA is composed of 1 or more proteins associated with small nuclear or cytoplasmic RNA species (snRNP) ranging in size from 80 to 350 nucleotides. Antibodies to ENA are common in patients with connective tissue. The presence and levels of anti-SSA and anti-SSB was analyzed using fluorescence-enzyme immunoassay (FEIA) and the normal range was considered <7 units/mL. Out of 647 patients with RA, 26 had anti-SSA and/or anti-SSB antibodies; 25 patients had anti-SSA (3.9%) and 7 had anti-SSB (1.1%). Only 13 participants had an anti-SSA level of >240 units/mL I am not sure what ANA <1 means. Usually it is represented as 1:40, 1:80, 1:360 etc. Any test which detects ANA in dilution more than 1:40 is considered positive. Other antibodies are in normal range. Sjogren's, scleroderma and other mixed connective tissue disorders are ruled out. To establish a diagnosis of lupus, dsDNA antibody should be. She was diagnosed with primary Sjogren's syndrome based on positive ANA, anti-SSA and anti-SSB titers as well as an abnormal Schirmer's test and a minor salivary gland biopsy focus score of 1-2 (Table 3). She was started on prednisone 45 mg/day with transient improvement, but developed subsequent worsening of her paranoia with more. Among the checked autoimmune markers (C3, C4, rheumatoid factor, antinuclear antibody, antineutrophil cytoplasmic antibodies, anti-ds DNA, anti-Sm, anti-SSA/Ro, anti-SSB/La, anti SCL-70, anti Jo-1, and anti-RNP antibodies), and immunoglobulin G, A, and M, only mild decreased C3 level (75.6 mg/dl; normal range, 79-152 mg/dl) and positive.
Thrombotic thrombocytopenic purpura (TTP) is a potentially lethal multisystem disorder which could be caused by autoimmune diseases. However, the concomitant occurrence of TTP and Sjögren's syndrome (SS) is an extremely uncommon scenario, especially in male patients. A 56-year-old Chinese male was admitted for the appearance of diffuse ecchymosis. Then he gradually developed transient. Urinary analysis was normal. Liver, renal functions and levels of creatine kinase (CK) were within normal range. Thyroid function normal. Erythrocyte sedimentation rate (ESR) and C reactive protein (CRP) normal. Immunoglobulin (Ig) G slightly high (17 g/L) and complements slightly low (C3 0.64 g/L, C4 0.14 g/L) An anti-ENA screen determines the levels of seven different autoantibodies including anti-Sm, anti-RNP, anti-SSA, anti-SSB, anti-Jo-1, anti-Scl 70 and anti-CENP-B. Each antibody (or combination of antibodies) is specific to a different collagen disease
.5 x 109/L (normal 1.0-4.0) and thrombocytopaenia with platelets of 92 x 109/L (normal 150-450). Creatinine was slightly elevated at 128 mmol/L (normal 40-85) Primary Sjogren syndrome (pSS) is a systemic autoimmune disease characterised by lymphocytic infiltration of exocrine glands and by a number of systemic manifestations, including those regarding the lung. Pulmonary involvement in pSS includes interstitial lung disease (ILD) and airway disease, together with lymphoproliferative disorders
A labial salivary gland biopsy (LSGB) plays an essential role in diagnosing Sjögren's syndrome (SS), but its clinical application is limited due to its invasiveness. Here, we present a handheld single snapshot multiple-frequency demodulation-spatial frequency domain imaging (SSMD-SFDI) device for a rapid optical biopsy of labial salivary glands noninvasively. The structural and. The level of IL-18 among patients with active lupus was Coagulation studies, including prothrombin time, partial found to be significantly increased compared with that in thromboplastin time, and fibrinogen, were normal (LDH 2,310 controls (mean ⫾ SD 1,034.37 ⫾ 535.9 pg/ml versus 208.7 ⫾ IU/liter [normal 200-480], creatinine 0.9 mg/dl. Neonatal lupus erythematosus (NLE) is a rare and acquired autoimmune disease caused by passive placental transfer of maternal autoantibodies, especially anti-SSA/Ro and anti-SSB/La antibodies [1,2].The most common presenting symptom of NLE is rash, and clinical manifestations of NLE include cutaneous, cardiac, hepatobiliary, hematologic, and central nervous system (CNS) manifestations [3,4]
Positive serum anti-SSA and/or anti-SSB or [positive rheumatoid factor and ANA ≥ 1:320]. Ocular staining score ≥ 3. Presence of focal lymphocytic sialadenitis with focus score ≥ 1 focus/4mm2 in labial salivary gland biopsies. Sjogren's Syndrome: Issues that the Hair Specialist May Encounter. A) Hair Loss from Telogen Effluviu Anti-SSA and/or anti-SSB occur in only 10-55% of patients with Sjögren's syndrome-associated neuropathy.4, 13, 14, 16, 25 By subtype of neuropathy, in one series, 53% of 36 patients with Sjögren's syndrome-associated sensory ganglionopathy had anti-SSA, whereas 11% had anti-SSB; 39% of patients with Sjögren's syndrome-associated small. A diagnosis of Sjogren's Syndrome requires either positive SSA/SSB or positive minor salivary gland biopsy, and an additional 3 out of 6 diagnostic criteria. A diagnosis of Sjogren's Syndrome in our patients was therefore assessed using the results of SSA/SSB positivity, Schirmer's test, and responses to ocular and oral symptom questions.
Anti-SSA/SSB-negative Sjogren's syndrome shows a lower prevalence of lymphoproliferative manifestations, and a lower risk of lymphoma evolution Autoimmun Rev , 14 ( 11 ) ( 2015 ) , pp. 1019 - 1022 [PMID: 26162302 Epidemiological data show that pSS is a relatively common disease and one of the most common rheumatic diseases of autoimmune and inflammatory origin; however, the incidence and prevalence may vary depending on the diagnostic criteria used. 10 The prevalence of pSS, based on various sources, ranges from 0.72-2.70% of the general population. Serum IgG level of ACA PSS group(17. 89 ±4. 08)g/L was close to the normal range,which was significantly lower than that of SSA PSS(27.90 ±6. 72)(P ＜0. 01). Leukocytopenia was less frequently observed in ACA PSS than in SSA PSS(P ＜ 0. 05),the difference between two groups was statistically significant. We also found more frequent RP in. Sun and Sjögren's Survival Tips. To reduce reactions to the sun, wear good Ultraviolet (UV)-protective eye lenses and sunglasses, and seek the shade when outside. Protect your skin and eyes through use of sunscreen, sunglasses, Ultraviolet (UV) light-protective clothing, hats, and non-fluorescent lighting
Abstract Aim To assess the clinical and laboratory features of primary Sjogren's syndrome (pSS) in a large teaching hospital in China. Methods Three hundred and fifteen pSS patients diagnosed accor.. Sjögren's syndrome is an autoimmune disease characterized by dryness of the mouth and eyes. Autoimmune diseases feature the abnormal production of extra antibodies in the blood that are directed against various tissues of the body. The misdirected immune system in autoimmunity tends to lead to inflammation of tissues
Introduction. Two types of anti-Ro/SSA antibodies have been identified. They are specific for two different Ro/SSA antigens of 60 kDa and 52 kDa [1, 2] derived from the RNP complex.Anti-SSA-60 kDa antibodies (aSSA60) are linked to certain disorders such as SS, SLE, neonatal lupus and congenital heart block .Even though anti-SSA-52 kDa antibodies (aSSA52) have recently been implicated in the. ANA came back positive (no titer information - it was just a positive/negative test I guess) and anti-SSA came back at 8.0 (negative range is 0.0 to 0.9). But RA factor, anti-centromere B antibodies, anti-dna (ds) qn, anti-jo-1, anti chromatin, anti scleroderma-70, rnp, anti-SSB, and smith antibodies are all normal . In Sjögren's, the immune system attacks a variety of different lubricating glands, and it can present as simply dryness in certain areas, joint pain and fatigue, or in.
Myositis/Sjögren's - anti-SSA. Antisynthetase syndrome - anti-Jo-1. Treatment of overlapping diseases involves immunosuppression, but the choice of medications is guided by the clinical features in a particular patient and tailored to the most severe or major disease manifestations . Sjögren syndrome is a systemic chronic inflammatory disorder characterized by lymphocytic infiltrates in exocrine organs. The disorder most often affects women, and the median age of onset is around 50 to 60 years. Most individuals with Sjögren syndrome present with sicca symptoms, such as xerophthalmia (dry eyes.
Autoimmune-related antibodies: Anti-SSA/Ro + +- The fasting plasma glucose levels were within the normal range during the follow-up examinations in the OGTT 1.5y and OGTT 3y despite the 180 min glucose levels (2.82 mmol/L) in the OGTT 1.5y being below the normal range (3.36 mmol/L). The patient had no hypoglycemia-related symptoms The value of miR-146a and miR-4484 expressions in the diagnosis of anti-SSA antibody positive Sjogren syndrome and the correlations with prognosis. Eur Rev Med Pharmacol Sci . (2018) 22:4800-5. doi: 10.26355/eurrev_201808_1561 Are you asking whether a Sjogren's patient may be misdiagnosed as having Alzheimer's as well as Sjogren's? I doubt that anyone has done a study to look specifically at frequency. Certainly, it's possible, though, especially if the patient isn't se.. Anti-Ro/SSA antibodies are among the most frequently detected autoantibodies against extractable nuclear antigens and have been associated with systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS). Although the presence of these autoantibodies is one of the criteria for the diagnosis and classification of SS, they are also sometimes seen in other systemic autoimmune diseases. In.
normal range. Blood hormone analysis, except the reduced level of parathyroid hormone (PTH) was normal. Tumor markers, with the exception of beta-2-microglobulin and chromogranin, were normal, Citation: Nevenka B, Ana B, Nataša M, Elvira Ð, Olivera B (2018) Hypokaliemia in primary Sjogren's Syndrome . Rheumatology (Sunnyvale) 8: 237 Primary Sjogren's syndrome can also present with these positive auto antibodies. Primary Sjogren's can be present without another autoimmune disease, but secondary Sjogren's is common in SLE and RA. I have RA and secondary Sjogren's. I have many of the same symptoms you describe. The worst for me is the ocular dryness and constant burning . Sjogren's syndrome is a chronic autoimmune disorder which affects the exocrine glands with lymphocytic infiltration, and occasionally involves central nervous system. It is usually rare and manifests as a lesion in the trigeminal nerve. Our case discusses the involvement of the oculomotor and abducens nerves along with the prevalence. The anti-Ro/SSA and anti-La/SSB antibody systems and the clinical significance of these antibodies are reviewed here. An overview of the ANAs important in SLE and in related autoimmune diseases and the clinical significance of autoantibodies directed against double-stranded (ds)DNA, U1 ribonucleoprotein (RNP), Sm, and ribosomal P proteins are.
Anti-ENA (Antibodies to Extractable Nuclear Antigens) Anti-La Anti-Ribonuclear Protein Anti-RNP (Anti-Ribonucleoprotein) Anti-Ro Anti-Sjogren's Syndrome Anti-Sm (Smith) Anti-Smith (SM) Antigen Anti-SSA (Anti-Sjogren's Syndrome A) Anti-SSB (Anti-Sjogren's Syndrome B) Anti-U(1)RNP (Anti-Ribonucleoprotein) Antibodies to Extractable Nuclear Antigens Autoantibodies to Jo 1 Antigen Autoantibodies to. . The patient presented to the emergency department, and initial investigations revealed severe hypokalemia of 2.1mmol/ L (reference range, 3.5-5.5mmol/L), hyper-chloremia of 116.0mmol/L (reference range, 98-111mmol/L), and hypophospha-temia of 0.42mmol/L (reference range, 0.97-1.61mmol/L). An.
A young lady, a known case of Sjogren's syndrome, presented to our hospital with hypokalemic flaccid paralysis requiring ventilatory support. She was investigated and found to have severe hypokalemia and metabolic acidosis. During her hospitalization, she had severe persistent carpopedal spasm with normal ionized calcium. Following further evaluation, there was evidence of hypomagnesemia The purpose of this study was to investigate the prevalence of cyclic citrullinated peptide antibodies (anti-CCP) in patients with primary Sjögren syndrome (pSS) and its correlation with clinical and laboratory data. We analysed the clinical and serological data of 155 consecutive patients with pSS. Among these, 14 were excluded due to fulfillment of American College of Rheumatology criteria. According to the American College of Rheumatology/European League Against Rheumatism (ACR-EULAR) criteria , a score of ≥4 is diagnostic of Sjögren's syndrome with labial salivary gland biopsy showing lymphocytic infiltrates, positive anti-SSA/Ro antibodies, positive Schirmer test less than 5 mm in five minutes, and salivary flow rate less.
The ENA ( extractable nuclear antigen) panel is a blood test that looks for antibodies to 6 or 7 different proteins in the body. These antibodies include: anti-Ro (also called anti-SSA) anti-La (also called anti-SSB) anti-Sm (anti-Smith antibody) anti-RNP (anti-ribonucleoprotein) anti-Jo-1. anti-Scl70. anti-centromere Autoimmune Disease Basics . Autoimmune disease happens when the body's natural defense system can't tell the difference between your own cells and foreign cells, causing the body to mistakenly attack normal cells. There are more than 80 types of autoimmune diseases that affect a wide range of body parts Figure 1. Screening and Diagnosis of Patients With Suspected Autoimmune or Rheumatic Disease or Rheumatoid Arthritis This figure was developed by Quest Diagnostics based on references 5, 8, 9, 11. anti smith antibody normal range. Uncategorized 1 second ago 0 Likes 0 Comments. Interpretation: Anti-Ro antibodies are found in 60 to 90% of patients with Primary Sjögrens syndrome and 30 to 40% of patients with SLE who appear to fall into specific subsets. Anti-Ro antibodies are found in the majority of patients with secondary Sjögrens syndrome whatever the primary disease.In SS, anti-Ro (usually associated with anti-La.
Hi & welcome. I'm in the SSA subgroup, too, and was told that SSA (anti-Ro) can be positive in either lupus or Sjogren's syndrome. BTW, these two conditions can co-exist. How Sjogren's is Dx'ed: per my lupus hardcover, Sjogren's tends to bring a VERY high ANA, as high as 1:2580 or more Although anti-SSA is probably the most prevalent autoantibody found in the general population, data are scarce10: in a Japanese study, 58/2181 (2.7%) healthy residents had detectable anti-SSA antibodies.11 Their observed prevalence of anti-SSA is only slightly lower to that we observed in the total RA population in the current study (3.9%), and. The degree of acidosis and electrolyte imbalances was concerning for concurrent connective tissue disease and autoimmune workup revealed elevated titers of antibodies for antinuclear antibody (ANA), Sjogren's syndrome-related antigen A (SSA-A), double-stranded deoxyribonucleic (dsDNA), with normal complement (C3, C4) levels
A 53-year-old woman was diagnosed as having autoimmune thyroiditis due to the swelling of thyroid and the positivity for anti-thyroid peroxidase antibody (anti-TPO ab) and anti-thyroglobulin antibody (anti-TG ab) 25 years ago, however, she did not require thyroxin substitution because her thyroid function test was normal Sjogren's Syndrome (SS) and a diagnostic accuracy assessment of salivary lymphocyte detection and immunophenotyping in Sjogren's Syndrome diagnosis and prognosis were performed. The study included 40 consecutive patients, aged 19-60 years, with parenchymal sialadenitis associated with Sjogren's Syndrome, and 20 healthy donors A second fetus (patient 1-23-9) had a normal PR interval of 135 ms at 19 weeks, missed the 20- and 21-week echocardiograms, and had a PR interval of 160 ms at 22 weeks, which decreased to 126 ms after 2 days of 4 mg dexamethasone. Dexamethasone was continued until 26 weeks when oligohydramnios was detected After the pathological diagnosis, on suspicion of an associated autoimmune disease, autoantibodies were examined and were positive for antinuclear antibodies (speckled type, ×640), rheumatic factor (114; normal range <15 IU/mL), and anti-SSA/Ro antibodies (>240; normal <10 U/mL) and negative for anti-SS-B/La, anti-DNA, anti-RNP, anti-Sm, anti. The Ro52/SS-A autoantigen has elevated expression at the brain microvasculature. Neuroreport. 2003 Oct 6;14(14):1861-5. Megevand P et al. Cerebrospinal fluid anti-SSA autoantibodies in primary Sjogren's syndrome with central nervous system involvement. Eur Neurol. 2007;57(3): 65 Clinical characteristics of children with positive anti-SSA/SSB antibodies. Rheumatol Int. 2014;34:1123-7. CAS PubMed Article Google Scholar 50. Virdee S, Greenan-Barrett J, Ciurtin C. A systematic review of primary Sjogren's syndrome in male and paediatric populations. Clin Rheumatol. 2017;36:2225-36