Oral squamous cell carcinoma (OSCC) is the most common type of oral cancer; it involves damage to oral epithelial cells due to accumulation of multiple genetic mutations in the cells. OSCC remains major cause of morbidity and mortality in patients with head and neck cancers Click here for Patient Education Oral cancer refers to cancer occurring between the vermilion border of the lips and the junction of the hard and soft palates or the posterior one third of the tongue. Over 95% of people with oral squamous cell carcinoma smoke tobacco, drink alcohol, or both
Oral squamous cell carcinoma (OSCC) is a major oral cancer subtype that is the fourth most common cancer affecting Taiwanese men Abstract Head and neck cancer, including oral squamous cell carcinoma (OSCC), is the sixth leading malignancy worldwide. OSCC is an aggressive tumor and its prognosis has exhibited little improvement in the last three decades Oral squamous cell carcinoma (OSCC) is the most common oral malignant neoplasm, mainly affecting individuals over 50 years old with a history of tobacco and alcohol use
Increasing evidence has revealed a significant association between microorganisms and oral squamous cell carcinoma (OSCC). Porphyromonas gingivalis, the keystone pathogen in chronic periodontitis, is considered an important potential etiologic agent of OSCC, but the underlying immune mechanisms through which P. gingivalis mediates tumor progression of the oral cancer remain poorly understood Among oral cancers, oral squamous cell carcinoma (OSCC) is the most prevalent and most commonly studied, and it is the most common malignancy of the head and neck worldwide. However, there is a void regarding the role that the oral microbiome may play in OSCC Limits of the available model have, in the long term, challenged the studies of cancer-associated fibroblasts (CAFs) and their interplay with cancer stem cells, one of the key driving forces of patients with oral squamous cell carcinoma (OSCC)
Squamous cell carcinoma (SCC) is the second most common form of skin cancer. It's usually found on areas of the body damaged by UV rays from the sun or tanning beds PeriRx is introducing SaliMark™ OSCC, its first commercial saliva test for the early detection of oral squamous cell carcinoma. According to the National Institutes of Health, oral cancer is the sixth most common cancer in the world The Southern California Geographic Area Coordination Center (OSCC) is the focal point for coordinating the mobilization of resources for wildland fire and other incidents throughout the Geographic Area. Located in Riverside, CA, the Center also provides Intelligence and Predictive Services related-products designed to be used by the internal wildland fire community for purposes of wildland.
Oral squamous cell carcinoma (OSCC) constitutes 90% of all cancers in the oral cavity, and the prognosis for patients diagnosed with OSCC is still poor. The identification of novel therapeutic targets and prognostic markers for OSCC is therefore essential. Previous studies of OSCC revealed an increased expression of WNT5A in the tumor tissue Oral squamous cell carcinoma (OSCC), a subset of HNSCC, accounts for 90% of all oral malignancies, and it has a poor five-year survival rate that has not changed in decades
The Association of Periodontal Disease and Oral Squamous Cell Cancer Depending upon the country, and the prevalence of existing risk factors, oral squamous cell carcinoma (OSCC) is generally considered to be among the top 10 most common types of malignancy OSCC, a common malignant tumor of the head and neck is the 6th most common cancer worldwide. Projected 5-year survival for OSCC is approximately 50%. Recently, incidence of oral cancer among young adults has been alarmingly elevated [2, 3], indicating that OSCC is an emerging public health concern
Oral cancer is a common cancer worldwide. Approximately 300,373 new cases were diagnosed in 2012, making oral cancer a growing health concern 1, 2. Oral squamous cell carcinoma (OSCC), which is the.. OSCC is generally considered the 8th most common cancer worldwide and is among the three most common cancers in South-Central Asia,. Despite therapeutic advances, the 5-year survival rate is approximately 50%, making OSCC one of the most devastating malignancies Oral cancer, predominantly oral squamous cell carcinoma (OSCC), is a significant health problem and is considered the leading cause of death from oral diseases in many countries . In this study, we analyze the effects of neutrophils in the invasion of oral squamous cell carcinoma (OSCC) using a combination of conditioned media, direct and indirect coculture of human peripheral blood neutrophils, and UMSCC47. Tonsillar cancer is the most common OSCC, followed by base of tongue cancer. Together, these 2 cancers account for 90% of all OSCCs (6, 9). Patients usually do not seek counseling until the tumors are large because small tumors cause little distress and may not be noticed by the patient
Oral squamous cell carcinoma (OSCC) is a malignant cancer, the survival rate of patients is disappointing. Therefore, it is necessary to identify the driven-genes and prognostic biomarkers in OSCC On the other hand, they found that CPAP protein levels were higher in EGF treated OSCC cells as well as in oral cancer tissues, suggesting that the frequently reported aberrant centriolar features.. Promoter Hypermethylation of Apoptotic Genes in OSCC. Cancer is one of those diseases whose treatment requires more rapid and potent response and epigenetic modifications have emerged into one amongst the cancer hallmarks, commutating the concept of malignant pathologies as being singlely genetic-based conditions Oral squamous cell carcinoma (OSCC) is one of the most common head and neck malignancies [ 1, 2 ]. There are more than 300,000 new cases each year, accounting for approximately 2 to 3% of all cancers worldwide [ 2 ] Squamous cell carcinoma of the oral cavity (OSCC) is a common cancer form with relatively low 5-year survival rates, due partially to late detection and lack of complementary molecular markers as targets for treatment. Molecular profiling of head and neck cancer has revealed biological similarities with basal-like breast and lung carcinoma
Introduction. Oral cancer is the most common location for head and neck cancers. Among all oral cancer subtypes, oral squamous cell carcinoma (OSCC) is the most common ().Despite the existence of mature diagnostic and comprehensive treatment methods, the 5-year survival rate of patients with OSCC remains relatively poor, and ~50% of patients with OSCC die within 5 years Head-and-neck cancer is located in the oral cavity in 48% of cases and 90% of these are oral squamous cell carcinoma (OSCC). OSCC develops from tobacco; it is a multistep and multifocal process involving field cancerization and carcinogenesis BACKGROUND/AIM: Oral squamous cell carcinoma (OSCC) is a cancer with poor prognosis due to therapy resistance, locoregional recurrences, and distant metastases.There is on increased interest in profiling the androgen receptor (AR) in cancer biology. The aim of this study was to compare AR and Ki-67 levels in the neoplastic epithelium and stroma between non-metastatic and metastatic stages of OSCC
Long non-coding RNAs (lncRNAs) have been confirmed to participate in cancer regulation, including oral squamous cell carcinoma (OSCC). The aim of the present study was to investigate the role of UASR1 in OSCC. The expression levels of UASR1, miR-375 and JAK2 were detected in OSCC tissues by reverse transcriptase quantitative PCR . This may be because lip cancer is noticed earlier by patients and so they tend to seek care earlier In a search for new prognostic markers in OSCC, we applied a data-mining approach that we had previously developed and used for the identification of cancer biomarkers in lung cancer [16, 17], B.
Introduction. Oral squamous cell carcinoma (OSCC) is a destructive and lethal malignant tumour that accounts for >90% of all oral cancers and is the sixth most common type of cancer worldwide ().Due to its anatomical location, OSCC affects patients seriously, and most of them have poor prognosis OSCC (oral squamous carcinoma) is one of most common malignant cancer. Although previous studies have found abnormal expression of B7-H3 in human OSCC, the exact role and molecular mechanism of B7-H3 in OSCC remain unknown Oral squamous cell carcinoma (OSCC), the eighth most prevalent cancer in the world, arises from the interaction of multiple factors including tobacco, alcohol consumption, and betel quid. Chemotherapeutic agents such as cisplatin, 5-fluorouracil, and paclitaxel have now become the first-line options for OSCC patients Oral squamous cell carcinoma of the gingivo-buccal region (OSCC-GB) accounts for the highest cancer morbidity and mortality among men in India. It has been observed that about one-third of. . Introduction. Head and neck cancer is one of the0 most common types of cancer worldwide, afflicting >500,000 individuals each year. Oral cancer is considered to be a preventable condition, due to the possibility of early detection and treatment ().Oral squamous cell carcinoma (OSCC) represents 95% of all forms of head and neck cancer, and during the past decade its incidence has increased.
Objective . Oral squamous cell carcinoma (OSCC) has a remarkable incidence over the world and a fairly strenuous prognosis, encouraging further research on the prognostic factors and new techniques for diagnosis that might modify disease outcome. Data Sources . A web-based search for all types of articles published was initiated using Medline/Pub Med, with the key words such as oral cancer. Introduction. Oral squamous cell carcinoma (OSCC) is the most common form of head and neck cancers with tongue and buccal mucosa being the most reported affected sites (Rivera and Venegas, 2014).According to GLOBOCAN survey 2018, oral cancer is the third most common cancer in India with an incidence rate of 8.9% (Bray et al., 2018).The major risk factors associated with development of oral. noma (OSCC), the head and neck cancer in which HPV is most commonly found (4). Head and neck cancer most commonly is of the squamous cell carcinoma type (HNSCC) and includes cancers of the oral cavity, oropharynx, hypopharynx, lar-ynx, sinonasal tract, and nasopharynx. HNSCC is the sixth most common type of cancer in the world; almost 600,00
Oral squamous cell carcinoma (OSCC) is the most common type of head and neck squamous cell carcinoma (HNSCC), and the effect of zymosan (ZYM), a component of the yeast cell wall, on oral cancer remains unclear. The CCK-8 proliferation assay was performed to evaluate the effect of ZYM on the proliferation of the OSCC cell lines WSU-HN4, WSU-HN6 and CAL27, and the potential mechanism was. Oral squamous cell carcinoma (OSCC) is the sixth most common tumor in the world and accounts for more than half of patients with oral cancer [[1, 2]]. Despite the great advances of cancer therapy, local recurrence and regional lymph node metastasis remain common in most patients with OSCC  . Even though surgery combined with radiotherapy or chemotherapy has made great progress, OSCC patients exhibit the 5-year survival rate of <60% on account of local invasion, metastases, and.
cancer (adenocarcinoma (OAC) and squamous cell carcinoma (OSCC)) and two subsites of GC (cardia (CGC) or proximal GC and non-cardia (NCGC) or distal GC) are distinguished. While OSCC occurs mostly in stratified squamous epithelium lining the upper two-thirds of the oesophagus, OAC typicall Introduction. In each year, oral squamous cell carcinoma (OSCC) gives rise to approximately 145 000 deaths worldwide, accounting for 2.1% of all cancer-related deaths.1 2 The 5-year overall survival rate of OSCC is only 40%-50% due to relatively low treatment responsiveness, drug resistance and late diagnosis.3 Therefore, it is urgent to explore the mechanism of OSCC progression for novel. Oesophageal cancer ranks sixth in cancer-associated deaths worldwide. It has been reported that 572,034 oesophageal cancer diagnoses and 508,585 deaths occurred in 2018 .In China, more than 95% of oesophageal cancer patients are diagnosed with oesophageal squamous cell carcinoma (OSCC) .Most patients are diagnosed with locally advanced OSCC ABO blood groups and OSCC were assessed by odds ratio, it was found that people with blood group A had 3.22 times higher risk of developing oral cancer compared to people of other blood groups, while the relative risk for people with blood group O was 0.58 times The relationship between cancer and coagulation has been intensively studied in recent years; however, the effects of coagulation factors on oral squamous cell carcinoma (OSCC) have rarely been reported. This study aimed to investigate the relationship between preoperative D-dimer (DD), fibrinogen (FIB), platelets (PLT) and OSCC, as well as the prognostic value of DD, FIB and PLT in OSCC
HPV can cause cancer, warts or have no effect. HPV is very common in the U.S. Over 20 million Americans have some type of genital or oral HPV infection. In some people, oral HPV infection leads to HPV-OSCC (HPV-positive oropharyngeal squamous cell cancer) after many years Introduction. Oral squamous cell carcinoma (OSCC) emerges as a deforming and fatal disease when oro-facial destruction, tumor invasion, blood-borne dissemination and cervical lymph node metastasis occur. 1 Tobacco, areca nut use, alcohol consumption and human papillomavirus (HPV) infection account for the majority of oral cancer. 2 Patients with oral cavity cancers have 55% five-year survival. Oral squamous cell carcinoma (OSCC), the most common type of oral cancer, is stated to be the sixth to eighth most common cancer worldwide .It occurs anywhere in the mouth, including the tongue, upper and lower gums, palate and buccal mucosa .The incidence of OSCC is on the rise globally and is the main cause of death Introduction. Head and neck cancer (HNC) is the seventh most common tumor with a high mortality rate worldwide. 1 Oral squamous cell carcinoma (OSCC) accounts for approximately 95% of all HNCs and affects approximately 400,000 people every year. 2 Although significant advances in surgery and other adjuvant treatments have greatly improved OSCC outcome, the 5-year survival rate of patients with. EGFR is significantly altered in OSCC and its prolonged signaling is mitogenic, driving uncontrolled proliferation of tumor cells. Despite these advances in the understanding of EGFR signaling, the regulatory mechanisms underlying EGFR signaling and their effects on cancer initiation, progression and metastasis are not fully understood
Oral squamous cell carcinoma (OSCC) is the most common malignancy of oral cancers, and results in more than 145 thousand mortality annually overworld .Traditional treatment options such as surgery, radiotherapy and chemotherapy failed to improve the 5 year survival rate yet, which is about 50% [2, 3].In the United States, the estimated numbers of new cases and deaths of OSCC have increased. Pretoria oral cancer database was retrospectively developed. Despite including all available OSCC cases at the University of Pretoria within the study period, the limited sample size in the study is a weakness. Chi-Square analysis becomes unreliable when data elements in subgroups are less than 5, which wa Author summary Oral squamous cell carcinoma (OSCC), a subset of HNSCC, is the most common malignant oral neoplasm. Risk factors, including smoking, alcohol consumption and human papilloma virus (HPV) infection alone have not been sufficient in explaining the incidence and aggressive behaviors of OSCC. Thus, other factors, such as oral periodontal pathogens may play an important role in OSCC. Loss of the tumor suppressor NDRG2 has been implicated in the development of oral squamous cell carcinoma (OSCC), acting by modulating PI3K/AKT-mediated dephosphorylation of PTEN at S380/S382/T383 (STT). Here, we show that the majority of OSCC tumors with lymph node metastasis, a major prognostic factor, exhibit high levels of phosphorylated AKT-S473 and PTEN-STT and low levels of NDRG2.
. Geographical differences in incidence and mortality, heterogeneity in anatomical localization, association with a broad spectrum of risk factors, and the unpredictable treatment outcome renders OSCC as one of the most complex cancer squamous cell carcinoma (OSCC). Purpose of our study was to explore the prognostic value of autophagy-related genes (ATGs) and screen autophagy-related biomarkers for OSCC. RNA-seq and clinical data were downloaded from The Cancer Genome Atlas (TCGA) database following extracting ATG expression profiles. Then, differ
Salivary miRNAs have been increasingly explored in the diagnosis of cancer over the last decade , including in head and neck cancer , and specifically for patients with salivary gland neoplasms , esophageal cancer , and OSCC . Protocols have included stimulated or unstimulated saliva for analysis of either whole saliva or salivary supernatant Genetic studies have revealed a critical role of the distal-less homeobox gene 5 () in the pathogenesis of ovarian cancer, lung cancer, and T-cell lymphoma; however, the role and underlying mechanisms of in oral squamous cell carcinoma (OSCC) are largely unknown. In this study, we demonstrated that is up-regulated in OSCC tissues and cell lines, [ Squamous cell carcinoma is the most common type of oral cancer, accounting for about nine out of every ten oral malignancies, and is a major cause of cancer morbidity and mortality2. It is also amongst the 10 most common malignancies in Pakistan, mostly involving patients above the age of 50 years, with a peak incidence in 6th to 7th decades3,4 Oral Cancer - Ætiological Factors. More than 90% of Oral Cancer is Oral Squamous Cell Carcinoma (OSCC). OSCC accounts for approx 2 - 4% of all cancers in the UK but is one of the most common cancers on the Indian subcontinent. Men are more frequently affected than women; most OSCC patients > 40 and the incidence of rises rapidly with age
Oral cancer, predominantly oral squamous cell carcinoma (OSCC), is a high-effect local disease in the oral cavity affecting over 300,000 people worldwide annually (1, 2). Patients with OSCC often present with symptoms at a late stage, and there is a high recurrence rate after treatment, especially in those with neck lymph node metastasis Background Immune landscape of cancer has been increasingly recognized as a key feature affecting disease progression, prognosis and therapeutic response. Here, we sought to comprehensively characterize the patterns of tumor-infiltrating immune cells (TIIs) in primary oral squamous cell carcinoma (OSCC) and develop immune features-derived models for prognostication and therapeutic prediction Human papillomavirus (HPV)-positive oral squamous cell carcinoma (OSCC) is increasing worldwide with typically higher grade and stage, while better prognosis. microRNAs (miRNAs) has been shown to play a critical role in cancer, however, their role in HPV-positive OSCC progression remains unclear. miRNA microarray was performed to identify differentially expressed miRNAs. qRT-PCR and FISH were.
Immunomodulatory aspects of cancer tissues include several cancer cell-intrinsic and extrinsic mechanisms controlled in the tumor micro environment (TME), which promote progression and often confer resistance to their therapy [ 1 ]. The progression from premalignant lesions to OSCC is a complicated multi step process Introduction. Oral squamous cell carcinoma (OSCC) is the most common cancer of the head and neck region. High morbidity and mortality is associated with this disease, but little improvement has been observed in the 5-year survival rate for patients with OSCC along the years ().One of the main prognostic factors for OSCC patients is advanced disease () ADAM17 is one of the main sheddases of the cells and it is responsible for the cleavage and the release of ectodomains of important signaling molecules, such as EGFR ligands. Despite the known crosstalk between ADAM17 and EGFR, which has been considered a promising targeted therapy in oral squamous cell carcinoma (OSCC), the role of ADAM17 in OSCC development is not clear Gingivo-buccal oral squamous cell carcinoma (OSCC-GB) is the most common cancer among men in India and is associated with high mortality. Although OSCC-GB is known to be quite different from tongue cancer in its genomic presentation and its clinical behavior, it is treated identically as tongue cancer. Predictive markers of prognosis and therapy that are specific to OSCC-GB are, therefore. SMGs in OSCC, OAC and other cancer types. SMGs identified by MutSig2CV are shown on the basis of their q values and mutational fractions. Comparisons were made between OSCC against OAC (A), OAC against pan-cancer (B), OSCC against pan-cancer (C). In (A), the red circle denotes the fraction in OSCC, and the blue circle denotes OAC
OSCC patients can't be screened early due to the lack of available diagnostic markers. In addition, due to the drug resistance, some patients with OSCC might suer from cancer recurrence. us, identifying the novel biomark-ers and eective targets is of great importance to OSCC research and management cancer. However, the underlying mechanism in cancer is still unknown. Therefore, it is necessary to elucidate the lncRNA function. Notably, many lncRNAs dysregulation are associated with Oral squamous cell carcinoma (OSCC) and affect various aspects of cellular homeostasis, including proliferation, survival, migration or genomic stability OSCC accounts for 90% of oesophageal cancer worldwide and is the predominant subtype in South-East and Central Asia . In Western countries, OAC predominates and, alarmingly, the rates of OAC have risen rapidly over the past 30 years in Western populations, with the highest incidence being in the UK and the Netherlands [ 4 , 8 , 9 ]